Barbiturate Toxicity

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Abstract
BARBITURATE TOXICITYThe rapid and accurate quantitation of barbiturates in blood and tissue has been made feasible in the past three years by the development of methods utilizing the ultraviolet spectrophotometer.1 , 2 These require only 5 to 10 cc. of specimen, and it is possible for the first time to determine the blood barbiturate concentration of a comatose patient in the emergency room as well as that of a dead person whose residual concentration is very low.Correlation of Barbiturate Level with State of ConsciousnessPreliminary studies of the concentration of pentothal in the blood during surgical anesthesia3 show that consciousness . . .