QUANTITATIVE COMPARISON OF ANTICHOLINERGIC AND ANTI-ARRHYTHMIC ACTIONS OF DISOPYRAMIDE AND QUINIDINE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 29  (5) , 527-532
Abstract
To estimate quantitative differences between disopyramide and quinidine, 2 experimental series were designed. To establish the atropinic potency of both drugs, pA2 [negative log of the concentration antagonist that reduces the effect of a double dose of agonist to that of a single dose] values were determined in rabbits right atria using acetylcholine as agonist. The capacity to prevent ventricular fibrillation in albino mice subjected to chloroform apnea was also tested using various doses of the drugs. An ED50 to each of the drugs was calculated and the relative antiarrhythmic potency was compared. Disopyramide showed in both experimental series to be a more potent agent than quinidine.

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