What Have We Learned about the Treatment of Idiopathic Membranous Nephropathy with Steroids?

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Abstract
Idiopathic membranous nephropathy, one of the many renal diseases to emerge as a clearly defined clinicopathological entity after the use of renal biopsy became widespread, is characterized by distinctive changes in the glomerular capillary wall, which thicken the basement membrane yet increase its permeability to protein.1 , 2 In most patients, these changes lead to the development of the nephrotic syndrome at some time during the course of the disease. Typically, the course is chronic and slowly progressive, but it is variable, and ultimately a spontaneous complete remission occurs in about a quarter of untreated cases and renal failure in an approximately . . .