Pharmacokinetics in Clinical Practice
- 3 May 1976
- journal article
- research article
- Published by American Medical Association (AMA)
- Vol. 235 (18) , 1987-1992
- https://doi.org/10.1001/jama.1976.03260440039020
Abstract
The pharmacokinetic concepts introduced and defined in a preceding article are now applied to the management of drug therapy for the individual patient. The factors that affect the time course of drug concentrations in plasma produced by repetitive administration include the dosing rate, total clearance, biologic half-life, and systemic availability of the drug. A clinical pharmacokinetics service can monitor drug concentrations in biologic fluids, design individualized drug-dosing regimens, and carry out pharmacokinetic diagnostic work-ups to help determine the reasons for a patient's unusual response to drug therapy. (JAMA235:1987-1992, 1976)Keywords
This publication has 4 references indexed in Scilit:
- Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with referencesJournal of Pharmacokinetics and Biopharmaceutics, 1975
- Absorption of digoxin from different oral preparations in normal subjects during steady stateClinical Pharmacology & Therapeutics, 1974
- Serum Concentrations of Free Diphenylhydantoin and their Relationship To Clinical IntoxicationEpilepsia, 1973
- Salicylate Accumulation Kinetics in ManNew England Journal of Medicine, 1972