INHIBITION OF AFLATOXIN B1-INDUCED CYTOTOXICITY AND BINDING TO DNA IN CULTURED RAT-LIVER CELLS BY NATURALLY OCCURRING FLAVONES

  • 1 January 1979
    • journal article
    • research article
    • Vol. 2  (4) , 1021-1028
Abstract
Four naturally occurring flavones, quercetin, fisetin, nobiletin and tangeritin, protect cultured rat liver epithelial-like cells [E3] against aflatoxin B1-induced cytotoxicity and inhibit the binding of [3H]aflatoxin B1 to cellular DNA. The methoxy-substituted flavones, nobiletin and tangeritin, show greater protection against cytotoxicity than do the hydroxy-substituted compounds, quercetin and fisetin.