Hyperactivation of Mammalian Target of Rapamycin (mTOR) Signaling by a Gain-of-Function Mutant of the Rheb GTPase
Open Access
- 1 July 2006
- journal article
- Published by Elsevier
- Vol. 281 (29) , 19793-19797
- https://doi.org/10.1074/jbc.c600028200
Abstract
No abstract availableKeywords
This publication has 21 references indexed in Scilit:
- TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?Current Opinion in Genetics & Development, 2005
- Biochemical and Functional Characterizations of Small GTPase Rheb and TSC2 GAP ActivityMolecular and Cellular Biology, 2004
- The GTPase-activating protein Rap1GAP uses a catalytic asparagineNature, 2004
- Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorderProceedings of the National Academy of Sciences, 2003
- DrosophilaRheb GTPase is required for cell cycle progression and cell growthJournal of Cell Science, 2003
- Rheb promotes cell growth as a component of the insulin/TOR signalling networkNature Cell Biology, 2003
- Rheb is an essential regulator of S6K in controlling cell growth in DrosophilaNature Cell Biology, 2003
- Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independentThe Journal of cell biology, 2002
- Somatic activation of the K-ras oncogene causes early onset lung cancer in miceNature, 2001
- The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase RhoNature Cell Biology, 2000