Inhibitory Actions of -Diethylaminoethyl Diphenyl-n-Propyl Acetate (SKF 525-A) on Muscle Contraction

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Abstract
SKF 525-A caused an increased tension in the isolated frog rectus abdominis muscle. After treatment with this substance (10 [mu]g/ml) the response to acetylcholine (Ach) was inhibited and could not be restored by washing. The inhibition differed from that seen after d-tubocurarine or atropine. In concentrations of 1.5 [mu]g/ml it first potentiated and then reduced the response of isolated rabbit ileum to Ach, an inhibition which disappeared on repeated washing. SKF 525-A raised the threshold of the frog gastrocnemius muscle to direct electrical stimulation. It also inhibited sexum cholin-esterase. While unexplained, these results demonstrate that SKF 525-A has actions beyond its well established ability to inhibit microsomal enzymes concerned in detoxication.

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