Ethyl glucuronide: on the time course of excretion in urine during detoxification
- 1 October 2002
- journal article
- Published by Wiley in Addiction Biology
- Vol. 7 (4) , 427-434
- https://doi.org/10.1080/1355621021000006035
Abstract
Ethyl glucuronide (EtG) is a promising new biological state marker of recent alcohol consumption that detects alcohol use reliably over a definite time period. Other currently available markers lack acceptable sensitivity and specificity. Our aim is to elucidate under naturalistic conditions the time course of EtG excretion in urine following alcohol consumption and to show how this can be utilized for monitoring and prognosis in patients. There are no other existing data on this issue to date. One hundred and thirty-eight urine samples from 28 male alcohol withdrawal patients were drawn every 3-24 hours for up to 94 hours after hospitalization. Breath ethanol concentration (mean) at hospitalization was 900 mg/L. Patient age in years was 40.3 (mean). Determination of urine EtG was performed by gas chromatography/mass spectrometry (GC/MS) with deuterium-labelled EtG as an internal standard. The strongest correlations (p<0.01) were found between EtG determinations in the different patient when breath ethanol concentrations (BEC) were 0 and 48 hours after BEC=0 (r=0.747), EtG 24 and 48 hours after BEC=0 (r=0.872), and in the time frame of detection (hours) of EtG and EtG 48 hours after BEC=0 (r=0.762). No significant correlation was found (Mann-Whitney test) between EtG concentrations in urine at different time points between the groups of patients with (a) 1 or less-2, (b) 3-4 or more previous hospitalizations, (c) a history of seizures (yes/no) or (d) an age above or below the median (40.5). EtG excretion in urine is not random, but seems rather to follow a kinetic profile. Furthermore our preliminary data indicate, that there is no significant difference for EtG concentration in urine when correlated to group variables such as age, seizures and hospitalizations.Keywords
This publication has 19 references indexed in Scilit:
- An abnormal phospholipid in rat organs after ethanol treatmentPublished by Wiley ,2001
- Ethyl glucuronide: a marker of recent alcohol consumption with clinical and forensic implicationsAlcohol, 2000
- Can ethyl glucuronide be determined in post-mortem body fluids and tissues?Alcohol and Alcoholism, 1999
- Formation of fatty acid ethyl esters in rat liver microsomesEuropean Journal of Biochemistry, 1999
- Ethylglucuronid — Evaluation eines neuen AlkoholmarkersPublished by Springer Nature ,1996
- Urinary excretion of 5-hydroxyindole-3-acetic acid and 5-hydroxytryptophol after oral loading with serotoninLife Sciences, 1992
- Presence of Nonoxidative Ethanol Metabolism in Human Organs Commonly Damaged by Ethanol AbuseScience, 1986
- Phosphatidylethanol formation in rat organs after ethanol treatmentBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1984
- The characterization by gas-liquid chromatography of ethyl β-D-glucosiduronic acid as a metabolite of ethanol in rat and manEuropean Journal of Pharmacology, 1967
- Ueber Glykuronsäurepaarung bei Stoffen der FettreiheNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1901