HIGH MURINE MAMMARY-TUMOR VIRUS EXPRESSION IN MILK IN A LOW MAMMARY-TUMOR MOUSE STRAIN AND HIGH-INCIDENCE OF MAMMARY-TUMOR IN HYBRIDS PRODUCED BY CROSSING WITH ANOTHER LOW MAMMARY-TUMOR MOUSE STRAIN

  • 1 March 1986
    • journal article
    • research article
    • Vol. 77  (3) , 244-249
Abstract
Large amounts of murine mammary tumor virus (MMTV) were expressed in milk from a low mammary tumor mouse strain called II-TES, established by crossbreeding DBA/2 mouse strain with two strains of Japanese pet mouse origin. The reciprocal hybrids of the II-TES strain and OZ-F strain, another low mammary tumor strain of Japanese pet mouse origin, developed early-appearing mammary tumors at a high rate, and large quantities of MMTV were expressed in the milk. These findings suggest that different regulatory genes control MMTV expression and mammary tumorigenesis.