Effects of prostaglandins E2 and 552-01552-01552-01on motility of small intestine in man

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Abstract
Interdigestive motility of the small intestine was examined in 23 fasted healthy volunteers following luminal administration of the prostaglandins E2 and F2α. Motility was monitored by means of water-perfused catheters measuring intraluminal pressure changes. The registration points were located 25 cm apart, in the proximal duodenum, at the angle of Treitz, and in the jejunum. Prostaglandin E2 administered intraduodenally delayed the initiation of the subsequent activity front. The interval to the next activity front was prolonged by a dose of 1.0 mg prostaglandin E2 from 79.5±9.5 min to 137.1±5.0 min (P2 (P2. Prostaglandin F2α at 2.5 or 5.0 mg given intraduodenally induced bursts of contractions with a frequency of 17.7± 0.8 contractions per minute and an amplitude of 10 to 110 mm Hg (P2 delays the initiation of activity fronts in the duodenum. In contrast, prostaglandin F2α changes the interdigestive motility pattern to one of intense contractile activity, which is different from the postprandial motility pattern.