Dehydroepiandrosterone: An anti‐obesity and anti‐carcinogenic agent
- 1 January 1981
- journal article
- Published by Taylor & Francis in Nutrition and Cancer
- Vol. 3 (1) , 46-53
- https://doi.org/10.1080/01635588109513700
Abstract
Long-term treatment of female C3H-Avy/A (obese) and C3H-A/A (non-obese) mice with dehydroepiandrosterone, an adrenal steroid found in subnormal levels in women predisposed to develop breast cancer, reduces weight gain without suppressing appetite and significantly inhibits the development of spontaneous breast cancer. This steroid also antagonizes the capacity of the tumor promoter, 12-0-tetradecanoyl-phorbol-13-acetate, to stimulate 3H-thymidine incorporation in mouse epidermis and in a cultured rat kidney epithelial cell line.Keywords
This publication has 14 references indexed in Scilit:
- Prevention of obesity in Avy/a mice by dehydroepiandrosteroneLipids, 1977
- Plasma dehydroepiandrosterone sulfate, androstenedione and cortisol, and urinary free cortisol excretion in breast cancerPublished by Elsevier ,1977
- Androgens in postmenopausal breast cancer: Excretion, production and interaction with estrogensJournal of Steroid Biochemistry, 1975
- The effects of steroids on glucose-6-phosphate dehydrogenaseJournal of Steroid Biochemistry, 1972
- RELATION BETWEEN URINARY ANDROGEN AND CORTICOID EXCRETION AND SUBSEQUENT BREAST CANCERThe Lancet, 1971
- pH as a Determinant of Cellular Growth and Contact InhibitionProceedings of the National Academy of Sciences, 1971
- INHIBITION OF MAMMALIAN GLUCOSE-6-PHOSPHATE DEHYDROGENASE BY STEROIDSProceedings of the National Academy of Sciences, 1960
- The Metabolism of DehydroisoandrosteronePublished by Elsevier ,1960
- Measurement of Cell Growth in Tissue Culture with a Phenol Reagent (Folin-Ciocalteau)Experimental Biology and Medicine, 1956
- Nutrition in Relation to CancerAdvances in Cancer Research, 1953