Correlation between rates of brain atrophy and cognitive decline in AD
- 1 May 1999
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 52 (8) , 1687
- https://doi.org/10.1212/wnl.52.8.1687
Abstract
Article abstract Twenty-nine untreated patients diagnosed with probable AD and 15 control patients underwent two or more clinical and volumetric MRI assessments with intervals ranging from 5 months to 6 years. The change in global cerebral volume for an individual was calculated by a novel method of registration and subtraction of serial scans. Rate of global cerebral volume loss correlated strongly with rate of change in Mini-Mental State Examination scores (r = 0.80, p < 0.001), implying clinical relevance to this marker of progression.Keywords
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