Efficient Heparin Assay for Monitoring Regional Heparinization and Hemodialysis

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Abstract
ACTIVE bleeding, the threat of bleeding or bleeding in the immediate past remains the only definite contraindication to the use of artificial-kidney hemodialysis.1 2 3 Predialysis heparinization of the patient to prevent blood coagulation in the extracorporeal circuit is considered to be largely responsible for exacerbations of such bleeding. Therefore, a technic of "regional heparinization" of the dialyzer circuit was devised by Gordon et al.4 to reduce the threat of hemorrhage. This procedure consisted of the infusion of heparin into the blood leaving the patient and of protamine into the blood re-entering the patient. This permitted adequate anticoagulation of the blood in . . .

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