Infectious Mononucleosis and Reye's Syndrome: A Fatal Case with Studies for Epstein-Barr Virus
- 1 November 1970
- journal article
- Published by American Academy of Pediatrics (AAP)
- Vol. 46 (5) , 776-780
- https://doi.org/10.1542/peds.46.5.776
Abstract
A 6-year-old boy developed toxic encephalopathy and severe hepatitis following the onset of infectious mononucleosis. The disease was fatal and autopsy showed brain edema, fatty necrosis of the liver, and a mononuclear infiltration of the liver, spleen, lymph nodes, and gastrointestinal tract. Impression smears of these organs and inoculation of organ suspensions into tissue culture failed to demonstrate antigens of the Epstein-Barr virus or to yield cytopathic effect. The patient's serum contained a high titer of antibody to Epstein-Barr virus.Keywords
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