Regulation of Flowering Time by Histone Acetylation inArabidopsis
- 5 December 2003
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 302 (5651) , 1751-1754
- https://doi.org/10.1126/science.1091109
Abstract
TheArabidopsisautonomous floral-promotion pathway promotes flowering independently of the photoperiod and vernalization pathways by repressingFLOWERING LOCUS C(FLC), a MADS-boxtranscription factor that blocks the transition from vegetative to reproductive development. Here, we report thatFLOWERING LOCUS D(FLD), one of sixgenes in the autonomous pathway, encodes a plant homolog of a protein found in histone deacetylase complexes in mammals. Lesions inFLDresult in hyperacetylation of histones inFLCchromatin, up-regulation ofFLCexpression, and extremely delayed flowering. Thus, the autonomous pathway regulates flowering in part by histone deacetylation. However, not all autonomous-pathway mutants exhibitFLChyperacetylation, indicating that multiple means exist by which this pathway repressesFLCexpression.Keywords
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