The direct combination of HPLC solute focusing with supercritical fluid chromatography and mass spectrometry to enhance sensitivity and improve identification of trace components in polar solvent extracts

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Abstract
A system for combining normal and reversed phase high‐performance liquid chromatography solute focusing with packed column supercritical fluid chromatography and supercritical fluid chromatography–mass spectrometry has been developed. The technique has been used to identify paracetamol and stanozolol in spiked plasma extracts and its utility for the analysis of a sample from a process waste stream is illustrated.