Base pairs and pseudo pairs observed in RNA–ligand complexes
- 21 August 2009
- journal article
- research article
- Published by Wiley in Journal of Molecular Recognition
- Vol. 23 (2) , 241-252
- https://doi.org/10.1002/jmr.978
Abstract
Previously, a geometric nomenclature was proposed in which RNA base pairs were classified by their interaction edges (Watson–Crick, Hoogsteen or sugar-edge) and the glycosidic bond orientations relative to the hydrogen bonds formed (cis or trans). Here, base pairs and pseudo pairs observed in RNA–ligand complexes are classified in a similar manner. Twenty-one basic geometric families are geometrically possible (18 for base pairs formed between a nucleic acid base and a ligand containing heterocycle and 3 families for pseudo pairs). Of those, 16 of them have been observed in X-ray and/or NMR structures. Copyright © 2009 John Wiley & Sons, Ltd.Keywords
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