New 6-Aryl-2-pyrones fromGentiana pedicellata*

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Abstract
Three new 6-aryl-2-pyrones, viz. pedicellin (1), pedicellanin (2), and pedicellatin (3), have been isolated from the whole plant of Gentiana pedicellata WALL., collected when in flower. The compounds have been characterized on the basis of chemical transformation and comprehensive spectral evidence. This is the first report of occurrence of 6-aryl-2-pyrones in a member of the family Gentianaceae. The other secondary metabolites, e.g. triterpene, secoiridoid, and degraded carotenoid, present in this species are typical of the Gentiana. 1 and 2 produced significant adaptogenic and anti-stress effects in animal models thereby justifying the use of the title species in popular medicine.