Chemosurgery for melanoma

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Abstract
Microscopically controlled excision of [skin] melanoma by the chemosurgical method ensures complete eradication of any unsuspected outgrowths from the clinically observed tumor mass. The method differs from chemosurgical techniques used for excision of cutaneous carcinomas in the following 2 respects. The tissues always are chemically fixed in situ before any incisions are made to minimize the chance of dissemination. An extra margin of tissues is removed after reaching a microscopically melanoma free plane to encompass possible outlying melanomatous satellites in the peritumoral lymphatics. In 103 cases of melanomas of the nodular, superficial spreading and lentigo maligna types, there were 86 determinate patients with a 5 yr cure rate of 50%. This is a high rate for a series in which 69% were nodular melanomas and 64% invaded subcutaneous tissues (Clark''s level 5).

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