CHLORPROTHIXENE AND AMTTRIPTYLINEt: INTERACTION WITH THIOPENTONE, CIRCULATORY EFFECT AND ANTISIALOGOGUE EFFECT

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Abstract
Evaluation of the interaction of chlorprothixene and amitriptyline with thiopentone, in dogs, showed that both of these have pharmacological properties which cause delayed recovery from anaesthesia. This effect is particularly strong with chlorprothixene. The effect on the circulatory response to tilt was measured with these two drugs in young healthy male subjects, and both caused orthostatic hypotension, which was rather severe in the case of chlorprothixene, and mild with amitriptyline. Tests of antisialogogue activity with chlorprothixene, on the same subjects, showed that this drug was inactive in this respect, although it is reported to exert very strong anticholinergic effects on other organ systems.

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