Bactericidal activity of cefoxitin and cefuroxime

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Abstract
Using the membrane filtration method the bactericidal activity of cefoxitin and cefuroxime was determined against Escherichia coli (n = 6), Klebsiella pneumoniae (n = 5) and Proteus mirabilis (n = 5). No significant difference in rate of killing was seen between the two compounds and the minimum inhibitory concentration (MIC) of the strains tested had no effect on the bactericidal activity. At 10 μg/ml both cefoxitin and cefuroxime rapidly reduced the viable count. The effect of concentration on kill-rate was evaluated against one strain of E. coli, K. pneumoniae, P. mirabilis and P. morganii. At an exposure time of 2 h, higher concentrations led to a greater decrease in the viable count.