Cancer in rodents: does it tell us about cancer in humans?
- 1 October 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 5 (10) , 807-819
- https://doi.org/10.1038/nrc1715
Abstract
Information obtained from animal models (mostly mice and rats) has contributed substantially to the development of treatments for human cancers. However, important interspecies differences have to be taken into account when considering the mechanisms of cancer development and extrapolating the results from mice to humans. Comparative studies of cancer in humans and animal models mostly focus on genetic factors. This review discusses the bio-epidemiological aspects of cancer manifestation in humans and rodents that have been underrepresented in the literature.Keywords
This publication has 90 references indexed in Scilit:
- Treating cancer with embryonic stem cells: rationale comes from aging studiesFrontiers in Bioscience-Landmark, 2005
- Neural Progenitor Cell Lines Inhibit Rat Tumor Growth in Vivo Cancer Research, 2004
- Insulin-like growth factors and neoplasiaNature Reviews Cancer, 2004
- Spontaneous and genetically engineered animal modelsEuropean Journal Of Cancer, 2004
- Comparative biology of mouse versus human cells: modelling human cancer in miceNature Reviews Cancer, 2003
- Inflammation and cancerNature, 2002
- Cancer genomicsCancer Cell, 2002
- Frequency and time trends of spontaneous tumors found in B6C3F1 mice oncogenicity studies over 10 yearsExperimental and Toxicologic Pathology, 2001
- The Hallmarks of CancerCell, 2000
- Control of Cell Proliferation by Embryonal‐Origin FactorsAmerican Journal of Reproductive Immunology, 1996