Solubilization of active opiate receptors.
Open Access
- 1 August 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (8) , 4623-4627
- https://doi.org/10.1073/pnas.77.8.4623
Abstract
Receptors that reversibly bind opiates and opioid peptides were solubilized from brain and neuroblastoma-glioma hybrid cell NG108-15 membranes. Active receptors are specifically solubilized with a new type of detergent 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate, which is a zwitterionic derivative of cholic acid. The solubilized receptor complexes behave as large molecules with a Stokes radius of 70 .ANG. and contain protein as an essential constituent.This publication has 15 references indexed in Scilit:
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