Protective Effect of a Tuberculosis Subunit Vaccine Based on a Fusion of Antigen 85B and ESAT-6 in the Aerosol Guinea Pig Model
Open Access
- 1 October 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (10) , 6148-6150
- https://doi.org/10.1128/iai.72.10.6148-6150.2004
Abstract
A fusion protein of antigen 85B (Ag85B) and ESAT-6 administered in cationic lipid vesicles conferred a highly significant level of protection against Mycobacterium tuberculosis in the guinea pig aerosol model of infection. The protection was manifested as delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently or as a cocktail) induced significant protection in this model.Keywords
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