Suppression of Pituitary TSH Secretion in the Patient with a Hyperfunctioning Thyroid Nodule

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Abstract
10 patients with a single hyperfunctioning thyroid nodule each were studied for pituitary thyrotropin (TSH) suppression. They were judged to be euthyroid on clinical grounds. The total thyroxine (T4D), free thyroxine (FT4), total triiodothyronine (T3D), and free triiodothyronine (FT3) were normal in most of the patients. Incorporation of 131I into the hyperfunctioning thyroid nodules was not suppressed by the administration of physiological doses of T3. Basal serum TSH concentrations were undetectable (4D, FT4, T3D, and FT3 may be associated with undetectable basal serum TSH concentrations and suppressed TSH response to TRH was also found in four hypothyroid patients given increasing doses of L-thyroxine and sequential TRH stimulation tests.

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