Diagnosis of Fabry's Disease by Tear α-Galactosidase a

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Abstract
To the Editor: The recent reports by Cotlier and Singer1 and by Carmody et al.2 indicate the advantages of human tears for the enzymatic diagnosis of homozygotes and especially heterozygotes for Tay-Sachs disease. In fact, the ease of collection and relative stability as compared to other tissue or fluid sources may make tears the enzyme source of choice for the convenient screening and diagnosis of many other inherited enzymatic deficiencies. We now report the extension of this technique for the diagnosis of hemizygotes and heterozygotes with Fabry's disease by the demonstration of deficient tear α-galactosidase A activity.Tears, fresh heparinized . . .

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