Defects in the Regulation of β-Catenin in Colorectal Cancer
- 1 January 1999
- book chapter
- Published by Springer Nature
- Vol. 470, 23-32
- https://doi.org/10.1007/978-1-4615-4149-3_3
Abstract
The molecular events that contribute to the progression of colon cancer are beginning to unravel. An initiating and probably obligatory event is the oncogenic activation of β-catenin. This can come about by the loss of its negative regulator the adenomatous polyposis coli (APC) protein, or by mutations in the β-catenin gene that result in a more stable protein product. The interaction between APC and β-catenin, and additional proteins that affect assembly and signaling along this pathway, are discussed.Keywords
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