Thymidine kinase of rat liver. Activation by phospholipase C and subcellular distribution in the liver
- 1 April 1971
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 122 (3) , 347-351
- https://doi.org/10.1042/bj1220347
Abstract
1. The thymidine kinase activity of rat liver is greatly enhanced on addition of phospholipase C to the assay mixture. 2. Most of the thymidine kinase activity of the liver is recovered in the mitochondrial and in the impure ‘nuclear’ fractions. No activity was detected in purified nuclei prepared in high-density sucrose. 3. A substantial thymidine kinase activity could be detected, with the aid of phospholipase C, in all rat tissues examined.Keywords
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