Synthesis and selective activity of cholinergic agents with rigid skeletons. I.

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Abstract
A common conformation was assumed to be involved in the potent muscarinic activities of L(+)-muscarine, acetylcholine and (+)-trans-2S-acetoxycyclopropyl-1S-trimethylammonium. The conformation of other muscarinic agents was considered from this point of view; 3 types of quaternary salts having semi-rigid piperidine ring structures which satisfy the hypothetical requirements were synthesized, and their muscarinic activities were examined. The synthetic compounds showed selective muscarinic activity.