Lipoprotein Lipase in Fat-Induced Hyperlipemia

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Abstract
Although able to hydrolyze a coconut-oil emulsion, the postheparin plasma of a patient with fat-induced (Type 5) hyperlipemia was unable to hydrolyze his own, normal human or rat chylomicrons. Postheparin plasma from normal controls were able to hydrolyze the emulsion and all chylomicron preparations. The inability of the patient's plasma to hydrolyze chylomicrons was not corrected by the addition of plasma (preheparin or postheparin) from normal subjects. The defect could not be produced in normal plasma by addition of the patient's plasma. Tests of lipolytic activity using the coconut-oil emulsion do not accurately reflect lipid-clearing ability. There appear to be at least two activities, one against the emulsion, and the other against chylomicrons. This and perhaps other Type 5 patients may lack the latter while possessing the former.

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