Hemodynamic and Catecholamine Changes after Administration of Naloxone

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Abstract
The hemodyanic and catecholamine response to i.v. administered naloxone 0.2 and 0.4 mg were determined in 1 group of surgical patients and 1 group of volunteers. Naloxone 0.2 mg was administered 30 min before the 0.4-mg dose. Group 1 consisted of 6 normotensive (1A) (aged 18-64, mean 35.7 yr) and 6 hypertensive surgical patients (1B) (aged 35-67 mean 49.1 yr) who were receiving a N2O, O2 and halothane anesthetic. Group 2 consisted of 6 normotensive (2A) (ged 27-38, mean 36.1 yr) and 5 hypertensive (2B) unanesthetized volunteers (aged 41-60, mean 51.4 yr). Mean arterial pressure, heart rate, plasma norepinephrine, epinephrine and dopamine levels were compared before and after i.v. naloxone. Changes in mean arterial pressure, heart rate, plasma norepinephrine, epinephrine and dopamine levels were not statistically significant in any group. Evidently, i.v. naloxone alters neither mean arterial pressure, heart rate or plasma catecholamine levels in normotensive or hypertensive humans.