LIPID-PEROXIDATION DURING CHRONIC INFLAMMATION INDUCED IN RATS BY FREUNDS-ADJUVANT - EFFECT OF VITAMIN-E AS MEASURED BY EXPIRED PENTANE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 37  (1) , 143-146
Abstract
Expired pentane, a product of .omega.-unsaturated fatty acid hydroperoxide decomposition, and foot volume were measured following injection of Freund''s adjuvant into the hind feet of vitamin E-deficient rats injected 1 wk previously with either 0 or 100 mg of dl-.alpha.-tocopherol acetate/100 g body weight. Vitamin E inhibited pentane production after 21 and 28 days. This is the first demonstration in vivo of increased lipid peroxidation and its inhibition by vitamin E during adjuvant-induced chronic inflammation. By 28 days, foot volume was significantly less in vitamin E-injected rats (162%) than in vitamin E-deficient rats (207%).

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