Action of the First Component of Complement
Open Access
- 1 January 1964
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 92 (1) , 108-112
- https://doi.org/10.4049/jimmunol.92.1.108
Abstract
Summary: The interaction of SAC′4 with guinea pig or human C′1 as they exist in whole serum yields an intermediate designated SAC′1,4. This intermediate is activated to SAC′1a,4 even in the absence of fluid phase serum factors at a rate which is dependent on temperature. Partially purified guinea pig C′1 was found to be in the activated state (C′1a) while partially purified human C′1 was found to be in the precursor form.Keywords
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