NITROGEN MUSTARD THERAPY COMPLICATED BY ACUTE RENAL FAILURE DUE TO URIC ACID CRYSTALLIZATION

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Abstract
Nitrogen mustard (methyl-bis (2 chloroethyl)amine) manifests certain toxic effects when used as a palliative agent against neoplastic diseases: (1) local (2) gastro-intestinal, and (3) hematopoietic. The pharmacology and measures to counteract these effects are discussed. Excess uric acid, produced by cell nuclear destruction during treatment, is excreted in the urine. A case is presented of bilateral ureteral obstruction and renal calculi due to uric acid precipitation following nitrogen mustard therapy. Treatment and preventive measures are explained, with special reference to fluid balance and alkalinization.

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