Haemoglobin Variants, β-Thalassaemia and G-6-PD Types in Liberia

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Abstract
Haemoglobin variants, β-thalassaemia and glucose-6-phosphate dehydrogenase (G-6-PD) types were studied in 702 individuals from Buchanan, Liberia. In this population haemoglobins S and C, β-thalassaemia and G-6-PD deficiency were found together. There was a considerable tribal variation. In the tribes of eastern Liberia the S- and C-genes were uncommon and the β-thalassaemia gene was rather frequent, while in western Liberia the S- and C-genes were more frequent and β-thalassaemia uncommon. In the central and northern parts the S- and β-thalassaemia genes were found together in relatively high frequencies, The rate of malaria infection was found to be lower in individuals with the sickle cell and β-thalassaemia traits than in individuals with haemoglobin AA, but the difference was not statistically significant. The frequency of the δ-chain gene B2 was 1.4% in the total material and there was no significant tribal variation for this gene. The frequency of G-6-PD deficiency estimated in males was 16%.

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