Long-Range Attraction and Molecular Rearrangements in Receptor-Ligand Interactions
- 13 March 1992
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 255 (5050) , 1419-1421
- https://doi.org/10.1126/science.1542789
Abstract
A surface force apparatus was used to measure a long-range attractive protein-ligand force at separations D less than 85 angstroms. This force may effectively "steer" ligand trajectories, resulting in a greater than 27-fold enhancement of the association rate. A much stronger specific attraction is measured at contact (D less than 4 angstroms). A sevenfold increase in intermembrane adhesion resulted from increased lateral mobility of the receptors and molecular rearrangements in membranes above the solid-fluid transition temperature.Keywords
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