Effects of immunopotentiating agents on the immune response of rainbow trout, Salmo gair dneri Richardson, to ERM vaccine

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Abstract
The use of Bacille Calmette Guerin (BCG) and the saponin Quil‐A as a means of potentiating the immune response elicited by immersion vaccination of Salmo gairdneri with a commercial enteric redmouth (ERM) vaccine was investigated. The bactericidal activity of trout serum to Yersinia ruckeri, the causative agent of ERM, was enhanced by vaccination, although non‐specific factors appear to serve an important defensive function. Whilst the use of BCG and Quil‐A produced no conclusive improvement of the immune response, as determined by bacterial agglutination and serum bactericidal activity, some enhancement of in vivo bacterial clearance was apparent. Differences were observed in the susceptibility to trout serum of the three strains of Y. ruckeri tested.

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