Salpingitis isthmica nodosa: radiologic and clinical correlates.

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Abstract
Salpingitis isthmica nodosa (SIN) is thought to be an inflammatory condition of the fallopian tubes and is strongly associated with infertility and an increased risk of ectopic pregnancy. The diagnosis is best made radiographically at hysterosalpingography (HSG), where the characteristic finding consists of multiple nodular diverticular spaces in close approximation to the true tubal lumen. The authors viewed 1194 HSG performed over a 5 yr period and identified 45 patients who had SIN (4%). There was a high rate of primary infertility (37.5%) and ectopic pregnancy (9.4%). Of 70 involved tubes, 62 (89%) had evidence of associated inflammation on historic, radiologic, surgical or histologic grounds. SIN is a disorder most likely acquired during the fertile years; the lesion is either a direct consequence of infection or that, once present, it predisposes the patient to subsequent infections.

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