Human Cytomegalovirus Immediate-Early 2 Gene Expression Blocks Virus-Induced Beta Interferon Production
Open Access
- 15 March 2005
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 79 (6) , 3873-3877
- https://doi.org/10.1128/jvi.79.6.3873-3877.2005
Abstract
The effect of human cytomegalovirus (HCMV) gene expression on beta interferon (IFN-β) expression was examined. We demonstrate that the HCMV immediate-early 2 (IE2) gene product IE86 can effectively block the induction of IFN-β during HCMV infection. IE86 also efficiently blocked the induction of IFN-β following Sendai virus infection, demonstrating that IE86's ability to block induction of IFN-β is not limited to HCMV infection, identifying IE2 as an IFN-β antagonist.Keywords
This publication has 23 references indexed in Scilit:
- Human Cytomegalovirus Elicits a Coordinated Cellular Antiviral Response via Envelope Glycoprotein BJournal of Virology, 2004
- The Ebola Virus VP35 Protein Inhibits Activation of Interferon Regulatory Factor 3Journal of Virology, 2003
- Altered Cellular mRNA Levels in Human Cytomegalovirus-Infected Fibroblasts: Viral Block to the Accumulation of Antiviral mRNAsJournal of Virology, 2001
- Viruses and InterferonsAnnual Review of Microbiology, 2001
- EnhanceosomesCurrent Opinion in Genetics & Development, 2001
- Ordered Recruitment of Chromatin Modifying and General Transcription Factors to the IFN-β PromoterCell, 2000
- The Human Cytomegalovirus 86-Kilodalton Major Immediate-Early Protein Interacts Physically and Functionally with Histone Acetyltransferase P/CAFJournal of Virology, 2000
- Acetylation of HMG I(Y) by CBP Turns off IFNβ Expression by Disrupting the EnhanceosomeMolecular Cell, 1998
- HOW CELLS RESPOND TO INTERFERONSAnnual Review of Biochemistry, 1998
- Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In VivoMolecular Cell, 1998