THE METABOLISM OF (R)-(-)-AMPHETAMINE BY RABBIT LIVER-MICROSOMES - INITIAL PRODUCTS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 10  (4) , 312-315
Abstract
The metabolism of l-amphetamine in rabbit liver is complex in that several routes may give rise to the same intermediate. The subsequent metabolism of the primary products of N- and C-oxidation were blocked by selecting appropriate incubation conditions. The resulting simplified system was used to investigate the enzymes involved in the 2 pathways. Phenobarbital treatment increased N- and C-hydroxylation, while 3-methylcholanthrene treatment had an inhibitory effect on both pathways. Inhibitors of cytochrome P-450 were either nonselective or partially selective in inhibiting the 2 routes of amphetamine metabolism. Induction modulated the sensitivity toward the inhibitors of N- and C-oxidation.