Absence of genetic variation in some obesity candidate genes (GLP1R, ASIP, MC4R, MC5R) among Pima Indians

25 February 1999

journal article
Published by Springer Nature in International Journal of Obesity

Vol. 23 (2) , 163-165
https://doi.org/10.1038/sj.ijo.0800786

Abstract

To examine the obesity candidate genes glucagon-like-peptide receptor (GLP1R), agouti signaling protein (ASIP) and the melanocortin receptors 4 and 5 (MC4R and MC5R) for DNA polymorphisms in their coding regions. Unrelated, non-diabetic Pima Indians (8 to 12 from each extreme of body fat). DNA sequencing within the coding regions of each gene. Only one variant was detected, a silent substitution in exon 6 of GLP1R. The exclusion of any common amino-acid polymorphisms (allele frequency > or = 0.20). implies that structural variants of these genes do not contribute to variation in the high level of obesity observed among the Pima Indians.

Keywords

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