Study of chronic schizophrenics using 31P magnetic resonance chemical shift imaging

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Abstract
Phosphorus‐31 chemical shift imaging showed regional abnormalities of in vivo31P NMR spectra in the brains of chronic schizophrenic patients. In the left temporal region, the level of % phosphodiesters (PDE) was increased and the level of %γαβ‐ATP (obtained by summation of γ‐ATP, α‐ATP, and β‐ATP) was decreased. In the basal ganglia, the levels of % PDE were decreased and the level of % phosphomonoesters was increased. The levels of %γαβ‐ATP were increased in the right basal ganglia. The level of % phosphocreatine was decreased in the frontoparietal region. These findings may represent different patterns of dysfunction of membrane phospholipid bilayers and high‐energy phosphate metabolism in the specific cerebral regions.