COMPARED VASODILATOR ACTIVITY OF DIHYDROERGOTOXINE, NICERGOLINE, PAPAVERINE, NAFTIDROFURYL AND BUFLOMEDIL ON THE DOG FEMORAL-ARTERY

  • 1 January 1982
    • journal article
    • research article
    • Vol. 13  (3) , 423-430
Abstract
Papaverine (PAP), naftidrofuryl (NAF), buflomedil (BUF), nicergoline (NIC) and dihydroergotoxine (DHT) were injected into the dog iliac artery at increasing doses (25, 100, 400 and 1600 .mu.g/kg) successively at 10 min intervals and the femoral blood flow was measured with an electromagnetic flowmeter. The same volume of saline was injected in the contralateral iliac artery. Heart rate and radial artery pressure were measured and the femoral resistance computed. Noradrenaline [norepinephrine] (2 .mu.g/kg) was injected before and after the highest dose of vasodilators. The 3 muscular vasodilators (PAP, BUF, NAF) had an immediate, powerful, dose-dependent but short lasting effect. After 1600 .mu.g/kg PAP, there was still a significant vasodilator effect after the 10th min. Little or no effect was observed on systemic blood pressure excepted for the higher doses of these compounds which produced a slight decrease accompanied by a simultaneous tachycardia. The 2 ergot derivatives NIC and DHT caused a moderate but much longer acting decrease of femoral resistance although 100 .mu.g/kg DHT also caused an increase of the femoral resistance. The higher dose of these compounds decreased systemic blood pressure and produced a slight bradycardia. The pressor effect of noradrenaline was reversed by NIC and DHT, confirming their .alpha.-adrenoceptor blocking properties.

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