AMINO-ACID CONFERRED PROTECTION AGAINST MELPHALAN - COMPARISON OF AMINO-ACIDS WHICH REDUCE MELPHALAN TOXICITY TO MURINE BONE-MARROW PRECURSOR CELLS (CFU-C) AND MURINE-L1210 LEUKEMIA-CELLS
- 1 January 1979
- journal article
- research article
- Vol. 23 (1) , 171-183
Abstract
The effect of the naturally occurring amino acids upon melphalan (L-phenylalanine mustard, L-PAM) [an antineoplastic drug] toxicity to a host sensitive tissue, the granulocyte and macrophage precursor cells of murine bone marrow (CFU-C), was investigated. At physiological concentrations the L isomers of leucine and glutamine were the most effective of the naturally occurring amino acids in reducing drug toxicity. Tyrosine, phenylalanine and methionine also protected murine CFU-C from melphalan toxicity although the amount of protection provided by these amino acids at physiological concentrations was less than that provided by leucine and glutamine. Little difference was observed in the pattern of amino acid protection of murine CFU-C and murine L1210 leukemia cells. Murine CFU-C however were more sensitive to melphalan in the absence and presence of amino acids.This publication has 3 references indexed in Scilit:
- EFFECT OF CORYNEBACTERIUM-PARVUM ON COLONY-STIMULATING FACTOR AND GRANULOCYTE-MACROPHAGE COLONY FORMATION1977
- AMINO ACID CONFERRED RESISTANCE TO MELPHALAN .1. STRUCTURE-ACTIVITY RELATIONSHIP IN CULTURED MURINE L1210 LEUKEMIA-CELLS1976
- The incorporation of 3H-cytosine arabinoside and its effect on murine leukemic cells (L5178Y)Biochemical Pharmacology, 1968