Pernicious Anemia in Childhood

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Abstract
PERNICIOUS anemia in childhood is a rare disorder. Only 25 definitely proved cases have been reported in the medical literature.1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 To establish this diagnosis, other causes of megaloblastic anemia — folic acid deficiency and vitamin B12 deficiency due to a general or specific intestinal absorptive defect — must be excluded. Thus, the diagnostic criteria include a megaloblastic anemia, absence of intrinsic factor from the gastric juice and impaired vitamin B12 absorption (corrected by the administration of intrinsic factor). Cases in which a clinical diagnosis of pernicious anemia had been made without the demonstration of the absence of intrinsic . . .