Synthesis and antibacterial activity of 3-acylamino-2-azetidinone-1-sulfonic acid derivatives.
- 1 January 1983
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 31 (6) , 1874-1884
- https://doi.org/10.1248/cpb.31.1874
Abstract
Sulfazecin (1) is a monocyclic β-lactam antibiotic isolated from strain G-6302, Pseudomonas acidophila. As a key intermediate for the synthesis of sulfazecin derivatives, 3-amino-2-azetidinone (16) was synthesized from penicillins, and various new compounds were synthesized by acylation and sulfonation of 16. Some of these new compounds showed potent antibacterial activity.Keywords
This publication has 6 references indexed in Scilit:
- Comparative in vitro study of SQ26,776Antimicrobial Agents and Chemotherapy, 1982
- Monocyclic β-lactam antibiotics produced by bacteriaNature, 1981
- Sulfazecin and isosulfazecin, novel β-lactam antibiotics of bacterial originNature, 1981
- Synthesis and structure-activity relationships of 7.BETA.-(2-(2-aminothiazol-4-yl)acetamido)cephalosporin derivatives. V. Synthesis and antibacterial activity of 7.BETA.-(2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido)cephalosporin derivatives and related compounds.The Journal of Antibiotics, 1981
- Synthesis and structure-activity relationships of 7.BETA.-(2-(2-aminothiazol-4-yl)acetamido)cephalosporin derivatives. IV. Synthesis of 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetic acid derivatives and related compounds.The Journal of Antibiotics, 1981
- Studies on β-Lactam Antibiotics for Medicinal Purpose. II. Synthesis of D (-)-α-[Dioxo-1-piperazinecarboxamido] benzylpenicillins and Structure-Antibacterial ActivityYAKUGAKU ZASSHI, 1977