Prostaglandins E2and F2αand acetylcholinesterase activity in the slices of some structures in the cat's brain

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Abstract
Prostaglandins E2 and F2α at small concentrations inhibit the acetylcholinesterase activity in slices of caudate nucleus, thalamus and hypothalamus of the cat brain in vitro condition. Prostaglandin E2 (PGE2) at concentrations of 0.35 μM and 0.70 μm produces a dose-dependent inhibition of acetycholinesterase activity in slices of caudate nucleus, thalamus and hypothalamus. Higher concentration of PGE2 (2.1 μm) produces less inhibition of acetylcholinesterase activity than smaller concentration of PGE2. The highest concentration of PGE2 (6.3 μm) produces even less inhibition of the same enzyme, which is not significant to the control values of the enzyme activity. Prostaglandin F2α (PGF2α) inhibits acetylcholinesterase activity in slices of thalamus and hypothalamus of the cat brain in a dose-dependent manner. In caudate nucleus the highest concentration of PGF2α produces somewhat less inhibition than smaller concentration of that prostaglandin. These results are discussed in the context of established potentiating effect of small doses of prostaglandins of gross behavioural changes induced by cholinomi-metic substances.