METABOLISM OF STEROID AND AMINO-ACID MOIETIES OF CONJUGATED BILE-ACIDS IN MAN .5. EQUATIONS FOR PERTURBED ENTEROHEPATIC CIRCULATION AND THEIR APPLICATION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 72  (1) , 141-148
Abstract
Equations previously developed to describe the enterohepatic circulation of the major biliary bile acids in man were modified to predict the effect on biliary bile acid composition and pattern of amino acid conjugation after prototypic perturbations of the enterohepatic circulation in man. For the steroid moiety, the effects of bile acid feeding, increased recycling frequency, decreased intestinal conservation and increased dehydroxylation were simulated. For the glycine or taurine moiety, the effect of increased deconjugation or preferential loss of 1 of the amino moieties was simulated. For the steroid moiety, the steady state biliary bild acid composition reflected the balance between input and conservation for each bile acid. The distribution of bile acids between glycine and taurine conjugates reflected the balance between conjugation and conservation for each amino acid moiety. Because these values varied widely and independently, analysis of biliary bile acid composition in terms of the steroid moiety or the glycine-taurine ratios per se could not be used to infer the relative rates of input or conjugation.

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