Comparison of Effects of d- and 1-Aldosterone on Excretion of Sodium and Potassium by the Adrenalectomized Rat

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Abstract
A preparation of 1-aldosterone, remaining after enzymatic reduction of the natural d-isomer of racemic aldosterone, showed very low biological activity, as measured by its effect on the excretion of sodium and potassium by adrenalectomized rats. The observed biological activity could be explained by the presence of a corresponding amount of d-aldosterone, which was greatly reduced by further treatments with liver homogenate.