Tumor-Necrotizing Serum Production by Administration of BCG + Pseudomonas: Its Application in Treatment of Fibrosarcoma in Mice
- 1 January 1980
- book chapter
- Published by Springer Nature
- Vol. 75, 220-225
- https://doi.org/10.1007/978-3-642-81491-4_34
Abstract
A Pseudomonas aeruginosa (i.v.) treatment (108 killed organisms) has shown the capacity to induce the release of tumor-necrotizing factor in the serum of BCG-pretreated mice to the same extent as an LPS treatment. Lower doses of P. aeruginosa (107 killed organisms) were applied in BCG-pretreated mice (1 mg given IV 7 days prior to or 1 day after tumor graft) bearing a methylcholanthrene-induced fibrosarcoma. In both cases this combined treatment significantly delayed tumor growth without a toxic side effect.Keywords
This publication has 6 references indexed in Scilit:
- Delayed tumor growth caused by a combined treatment with BCG and Pseudomonas aeruginosaCancer Immunology, Immunotherapy, 1978
- Tumour-necrosis factor from the rabbit. II. Production by monocytesBritish Journal of Cancer, 1978
- Tumour-necrosis factor from the rabbit. I. Mode of action, specificity and physicochemical propertiesBritish Journal of Cancer, 1978
- Corynebacterium parvum as the Priming Agent in the Production of Tumor Necrosis Factor in the Mouse2JNCI Journal of the National Cancer Institute, 1977
- Partial purification of a serum factor that causes necrosis of tumors.Proceedings of the National Academy of Sciences, 1976
- An endotoxin-induced serum factor that causes necrosis of tumors.Proceedings of the National Academy of Sciences, 1975